| State | Senator | Party | Reelection | 2020 Winner |
| Alabama | Tommy Tuberville | Republican | 2026 | Trump |
| Alabama | Katie Britt | Republican | 2028 | Trump |
| Alaska | Dan Sullivan | Republican | 2026 | Trump |
| Alaska | Lisa Murkowski | Republican | 2028 | Trump |
| Arizona | Kyrsten Sinema | Independent | 2024 | Biden |
| Arizona | Mark Kelly | Democratic | 2028 | Biden |
| Arkansas | John Boozman | Republican | 2028 | Trump |
| Arkansas | Tom Cotton | Republican | 2026 | Trump |
| California | Laphonza Butler | Democratic | 2024 | Biden |
| California | Alex Padilla | Democratic | 2028 | Biden |
| Colorado | John Hickenlooper | Democratic | 2026 | Biden |
| Colorado | Michael Bennet | Democratic | 2028 | Biden |
| Connecticut | Christopher Murphy | Democratic | 2024 | Biden |
| Connecticut | Richard Blumenthal | Democratic | 2028 | Biden |
| Delaware | Christopher Coons | Democratic | 2026 | Biden |
| Delaware | Thomas Carper | Democratic | 2024 | Biden |
| Florida | Rick Scott | Republican | 2024 | Trump |
| Florida | Marco Rubio | Republican | 2028 | Trump |
| Georgia | Jon Ossoff | Democratic | 2026 | Biden |
| Georgia | Raphael Warnock | Democratic | 2028 | Biden |
| Hawaii | Brian Schatz | Democratic | 2028 | Biden |
| Hawaii | Mazie Hirono | Democratic | 2024 | Biden |
| Idaho | James Risch | Republican | 2026 | Trump |
| Idaho | Mike Crapo | Republican | 2028 | Trump |
| Illinois | Richard Durbin | Democratic | 2026 | Biden |
| Illinois | Tammy Duckworth | Democratic | 2028 | Biden |
| Indiana | Mike Braun | Republican | 2024 | Trump |
| Indiana | Todd Young | Republican | 2028 | Trump |
| Iowa | Chuck Grassley | Republican | 2028 | Trump |
| Iowa | Joni Ernst | Republican | 2026 | Trump |
| Kansas | Jerry Moran | Republican | 2028 | Trump |
| Kansas | Roger Marshall | Republican | 2026 | Trump |
| Kentucky | Mitch McConnell | Republican | 2026 | Trump |
| Kentucky | Rand Paul | Republican | 2028 | Trump |
| Louisiana | Bill Cassidy | Republican | 2026 | Trump |
| Louisiana | John Kennedy | Republican | 2028 | Trump |
| Maine | Angus King | Independent | 2024 | Biden |
| Maine | Susan Collins | Republican | 2026 | Biden |
| Maryland | Ben Cardin | Democratic | 2024 | Biden |
| Maryland | Chris Van Hollen | Democratic | 2028 | Biden |
| Massachusetts | Edward Markey | Democratic | 2026 | Biden |
| Massachusetts | Elizabeth Warren | Democratic | 2024 | Biden |
| Michigan | Debbie Stabenow | Democratic | 2024 | Biden |
| Michigan | Gary Peters | Democratic | 2026 | Biden |
| Minnesota | Tina Smith | Democratic | 2024 | Biden |
| Minnesota | Amy Klobuchar | Democratic | 2024 | Biden |
| Mississippi | Roger Wicker | Republican | 2024 | Trump |
| Mississippi | Cindy Hyde-Smith | Republican | 2026 | Trump |
| Missouri | Josh Hawley | Republican | 2024 | Trump |
| Missouri | Eric Schmitt | Republican | 2028 | Trump |
| Montana | Jon Tester | Democratic | 2024 | Trump |
| Montana | Steve Daines | Republican | 2026 | Trump |
| Nebraska | Pete Rickets | Republican | 2026 | Trump |
| Nebraska | Deb Fischer | Republican | 2024 | Trump |
| Nevada | Catherine Cortez Masto | Democratic | 2028 | Biden |
| Nevada | Jackie Rosen | Democratic | 2024 | Biden |
| New Hampshire | Jeanne Shaheen | Democratic | 2026 | Biden |
| New Hampshire | Margaret Hassan | Democratic | 2028 | Biden |
| New Jersey | Cory Booker | Democratic | 2026 | Biden |
| New Jersey | Robert Menendez | Democratic | 2024 | Biden |
| New Mexico | Martin Heinrich | Democratic | 2024 | Biden |
| New Mexico | Ben Lujan | Democratic | 2026 | Biden |
| New York | Chuck Schumer | Democratic | 2028 | Biden |
| New York | Kirsten Gillibrand | Democratic | 2024 | Biden |
| North Carolina | Ted Budd | Republican | 2028 | Trump |
| North Carolina | Thom Tillis | Republican | 2026 | Trump |
| North Dakota | Kevin Cramer | Republican | 2024 | Trump |
| North Dakota | John Hoeven | Republican | 2028 | Trump |
| Ohio | J.D. Vance | Republican | 2028 | Trump |
| Ohio | Sherrod Brown | Democratic | 2024 | Trump |
| Oklahoma | James Inhofe | Republican | 2026 | Trump |
| Oklahoma | James Lankford | Republican | 2028 | Trump |
| Oregon | Jeff Merkley | Democratic | 2026 | Biden |
| Oregon | Ron Wyden | Democratic | 2028 | Biden |
| Pennsylvania | John Fetterman | Democratic | 2028 | Biden |
| Pennsylvania | Robert Casey | Democratic | 2024 | Biden |
| Rhode Island | Jack Reed | Democratic | 2026 | Biden |
| Rhode Island | Sheldon Whitehouse | Democratic | 2024 | Biden |
| South Carolina | Lindsey Graham | Republican | 2026 | Trump |
| South Carolina | Tim Scott | Republican | 2028 | Trump |
| South Dakota | John Thune | Republican | 2028 | Trump |
| South Dakota | Mike Rounds | Republican | 2026 | Trump |
| Tennessee | Bill Hagerty | Republican | 2026 | Trump |
| Tennessee | Marsha Blackburn | Republican | 2024 | Trump |
| Texas | John Cornyn | Republican | 2026 | Trump |
| Texas | Ted Cruz | Republican | 2024 | Trump |
| Utah | Mike Lee | Republican | 2028 | Trump |
| Utah | Mitt Romney | Republican | 2024 | Trump |
| Vermont | Bernie Sanders | Independent | 2024 | Biden |
| Vermont | Peter Welch | Democratic | 2028 | Biden |
| Virginia | Mark Warner | Democratic | 2026 | Biden |
| Virginia | Tim Kaine | Democratic | 2024 | Biden |
| Washington | Maria Cantwell | Democratic | 2024 | Biden |
| Washington | Patty Murray | Democratic | 2028 | Biden |
| West Virginia | Joe Manchin | Democratic | 2024 | Trump |
| West Virginia | Shelley Moore Capito | Republican | 2026 | Trump |
| Wisconsin | Ron Johnson | Republican | 2028 | Biden |
| Wisconsin | Tammy Baldwin | Democratic | 2024 | Biden |
| Wyoming | John Barrasso | Republican | 2024 | Trump |
| Wyoming | Michael Enzi | Republican | 2026 | Trump |
118th Senate (Jan. 2023 - Jan. 2025)