Here is a list of the 2022 Senate candidates as far as they are current known. The color of each line indicates which party currently holds the seat. An asterisk after a candidate's name indicates that he or she is an incumbent running for reelection.
| State | Democrat | Republican | 2016 Result |
| Alaska | Pat Chesbro | Lisa Murkowski* | 15% R |
| Alabama | Will Boyd | Katie Britt | 26% R |
| Arkansas | Natalie James | John Boozman* | 28% R |
| Arizona | Mark Kelly* | Blake Masters | 13% R |
| California | Alex Padilla* | Mark Meuser | No GOP |
| Colorado | Michael Bennet* | Joe O`Dea | 6% D |
| Connecticut | Richard Blumenthal* | Leora Levy | 29% D |
| Florida | Val Demings | Marco Rubio* | 8% R |
| Georgia | Raphael Warnock* | Herschel Walker | 14% R |
| Hawaii | Brian Schatz* | Bob McDermott | 51% D |
| Iowa | Michael Franken | Chuck Grassley* | 26% R |
| Idaho | David Roth | Mike Crapo* | 38% R |
| Illinois | Tammy Duckworth* | Kathy Salvi | 15% D |
| Indiana | Thomas McDermott | Todd Young* | 10% R |
| Kansas | Mark Holland | Jerry Moran* | 30% R |
| Kentucky | Charles Booker | Rand Paul* | 15% R |
| Louisiana | Candidate unknown | John Kennedy* | 21% R |
| Maryland | Chris Van Hollen* | Chris Chaffee | 25% D |
| Missouri | Trudy Valentine | Eric Schmitt | 3% R |
| North Carolina | Cheri Beasley | Ted Budd | 6% R |
| North Dakota | Katrina Christiansen | John Hoeven* | 62% R |
| New Hampshire | Maggie Hassan* | Don Bolduc | 0.1% D |
| Nevada | Catherine Cortez_Masto* | Adam Laxalt | 2% D |
| New York | Chuck Schumer* | Joe Pinion | 53% D |
| Ohio | Tim Ryan | J.D. Vance | 21% R |
| Oklahoma | Madison Horn | James Lankford* | 43% R |
| Oklahoma special | _OX!D | _OX!R | 74% R |
| Oregon | Ron Wyden* | Jo-Rae Perkins | 23% D |
| Pennsylvania | John Fetterman | Mehmet Oz | 2% R |
| South Carolina | Krystle Matthews | Tim Scott* | 24% R |
| South Dakota | Brian Bengs | John Thune* | 68% R |
| Utah | Evan McMullin (I) | Mike Lee* | 41% R |
| Vermont | Peter Welch | Gerald Malloy | 28% D |
| Washington | Patty Murray* | Tiffany Smiley | 18% D |
| Wisconsin | Mandela Barnes | Ron Johnson* | 3% R |