Here is a list of the 2022 Senate candidates as far as they are current known. The color of each line indicates which party currently holds the seat. An asterisk after a candidate's name indicates that he or she is an incumbent running for reelection.
| State | Democrat | Republican | 2016 Result |
| Alaska | Candidate unknown | Lisa Murkowski* | 15% R |
| Alabama | Candidate unknown | Candidate unknown | 26% R |
| Arkansas | Candidate unknown | John Boozman* | 28% R |
| Arizona | Mark Kelly* | Candidate unknown | 13% R |
| California | Alex Padilla* | Candidate unknown | No GOP |
| Colorado | Michael Bennet* | Candidate unknown | 6% D |
| Connecticut | Richard Blumenthal* | Candidate unknown | 29% D |
| Florida | Candidate unknown | Marco Rubio* | 8% R |
| Georgia | Raphael Warnock* | Candidate unknown | 14% R |
| Hawaii | Brian Schatz* | Candidate unknown | 51% D |
| Iowa | Candidate unknown | Chuck Grassley* | 26% R |
| Idaho | Candidate unknown | Mike Crapo* | 38% R |
| Illinois | Tammy Duckworth* | Candidate unknown | 15% D |
| Indiana | Candidate unknown | Todd Young* | 10% R |
| Kansas | Candidate unknown | Jerry Moran* | 30% R |
| Kentucky | Candidate unknown | Rand Paul* | 15% R |
| Louisiana | Candidate unknown | John Kennedy* | 21% R |
| Maryland | Chris Van_Hollen* | Candidate unknown | 25% D |
| Missouri | Candidate unknown | Candidate unknown | 3% R |
| North Carolina | Candidate unknown | Candidate unknown | 6% R |
| North Dakota | Candidate unknown | John Hoeven* | 62% R |
| New Hampshire | Maggie Hassan* | Candidate unknown | 0.1% D |
| Nevada | Catherine Cortez_Masto* | Adam Laxalt | 2% D |
| New York | Chuck Schumer* | Candidate unknown | 53% D |
| Ohio | Candidate unknown | Candidate unknown | 21% R |
| Oklahoma | Candidate unknown | James Lankford* | 43% R |
| Oregon | Ron Wyden* | Candidate unknown | 23% D |
| Pennsylvania | Candidate unknown | Candidate unknown | 2% R |
| South Carolina | Candidate unknown | Tim Scott* | 24% R |
| South Dakota | Candidate unknown | John Thune* | 68% R |
| Utah | Candidate unknown | Mike Lee* | 41% R |
| Vermont | Candidate unknown | Candidate unknown | 28% D |
| Washington | Patty Murray* | Candidate unknown | 18% D |
| Wisconsin | Candidate unknown | Ron Johnson* | 3% R |